Modeling and Analysis of Protein Design under Resource Constraints
نویسندگان
چکیده
منابع مشابه
Modeling and Analysis of Protein Design under Resource Constraints
The potency, or fitness, of a protein-based drug can be enhanced by changing the sequence of its underlying protein. We present a novel stochastic model for the sequence-fitness relation, and estimate its four parameters from industrial data. Using this model, we formulate and analyze two variants of the protein design problem. In the single-period design problem, the designer needs to decide u...
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ژورنال
عنوان ژورنال: Journal of Computational Biology
سال: 2005
ISSN: 1066-5277,1557-8666
DOI: 10.1089/cmb.2005.12.247